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English Translation :
Madam,
among the many samples of "atmospheric filaments" which were sent to us, we chose the three most similar to those
taken by you (référence121112-04, Dumas-18 provenance 18100 Thénioux), so :

- référence 121119-01, Duclaud-49 provenance 49350 Saint Clément des Levées
- référence 121109-01, Laxenaire-13 provenance 13310 Saint Martin de Crau
- référence 121203-01, Lumpkin-32 provenance 32730 Malabat

For each of these four (4) samples, two (2) thermal desorption experiments were carried out at 445 ° C, first directly and
on the other hand with in-situ methylation (promoting the detection process of the polar component may be present).
Different organic compounds generated in these eight (8) experiences have each time been separated by gas chromatography and identified
by mass spectrometry.
The data obtained were analyzed and detailed results are summarized in the following pages.
In conclusion to our study :
The "atmospheric filaments " collected in this investigation prove composition made ??up of complex organic polymers,
containing chemicals synthesis , as demonstrated by our screening GC / MS systematic products begin
during the process of thermal decomposition at 445 ° C.
Among the detected components are numerous molecules commonly found in the composition of fuels and lubricants
aircraft engine .
The four (4 ) samples of "atmospheric filaments " subject to this study contain toxic aromatic compounds (phthalates ) and
heterocyclic compounds of concern , and three of them contain DEHP , a particular concern representative of the family
phthalates (due to its endocrine disrupting properties ) .
All organic molecules and highlighted in the composition of the analyzed "atmospheric filaments " are problematic, as
in terms of public health and their environmental impact.
Given the increasing global nature of air traffic, if these " atmospheric filaments " result - as we believe - in
recombination phenomena in altitude releases of aviation engines, the results of this study constitute us as a
sufficient to inform the general public of this form of air pollution because , so far totally ignored the community
Scientific .
focus

Endocrine disruptor
From Wikipedia, the free encyclopedia


Endocrine disruptors are chemicals that at certain doses, can interfere with the endocrine (or hormone system) in mammals. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.Any system in the body controlled by hormones, can be derailed by hormone disruptors. Specifically, endocrine disruptors may be associated with the development of learning disabilities, severe attention deficit disorder, cognitive and brain development problems; deformations of the body (including limbs); breast cancer, prostate cancer, thyroid and other cancers; sexual development problems such as feminizing of males or masculine effects on females, etc.[citation needed] The critical period of development for most organisms is between the transition from a fertilized egg, into a fully formed infant. As the cells begin to grow and differentiate, there are critical balances of hormones and protein changes that must occur. Therefore, a dose of disrupting chemicals may do substantial damage to a developing fetus (baby). The same dose may not significantly affect adult mothers.

There has been controversy over endocrine disruptors, with some groups calling for swift action by regulators to remove them from the market, and regulators and other scientists calling for further study. Some endocrine disruptors have been identified and removed from the market (for example, a drug called diethylstilbestrol), but it is uncertain whether some endocrine disruptors on the market actually harm humans and wildlife at the doses to which wildlife and humans are exposed. Additionally, a key scientific paper, published in the journal Science, which helped launch the movement of those opposed to endocrine disruptors, was retracted and its author found to have committed scientific misconduct.

Found in many household and industrial products, endocrine disruptors are substances that "interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism)." They are sometimes also referred to as hormonally active agents,endocrine disrupting chemicals, or endocrine disrupting compounds (EDCs).

Studies in cells and laboratory animals have shown that EDs can cause adverse biological effects in animals, and low-level exposures may also cause similar effects in human beings. The term endocrine disruptor is often used as synonym for xenohormone although the latter can mean any naturally occurring or artificially produced compound showing hormone-like properties (usually binding to certain hormonal receptors). EDCs in the environment may also be related to reproductive and infertility problems in wildlife and bans and restrictions on their use has been associated with a reduction in health problems and the recovery of some wildlife populations.

Health effects attributed to endocrine disrupting compounds include a range of reproductive problems (reduced fertility, male and female reproductive tract abnormalities, and skewed male/female sex ratios, loss of fetus, menstrual problems; changes in hormone levels; early puberty; brain and behavior problems; impaired immune functions; and various cancers.

Endocrine system
Main article: Endocrine system

Endocrine systems are found in most varieties of animals. The endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones.

Hormones travel throughout the body and act as chemical messengers. Hormones interface with cells that contain matching receptors in or on their surfaces. The hormone binds with the receptor, much like a key would fit into a lock. The endocrine system regulates adjustments through slower internal processes, using hormones as messengers. The endocrine system secretes hormones in response to environmental stimuli and to orchestrate developmental and reproductive changes. The adjustments brought on by the endocrine system are biochemical, changing the cell's internal and external chemistry to bring about a long term change in the body. These systems work together to maintain the proper functioning of the body through its entire life cycle. Sex steroids such as estrogens and androgens, as well as thyroid hormones, are subject to feedback regulation, which tends to limit the sensitivity of these glands.

Hormones work at very small doses (part per billion ranges). Endocrine disruption can thereby also occur from low-dose exposure to exogenous hormones or hormonally active chemicals that can interfere with receptors for other hormonally mediated processes. Furthermore, since endogenous hormones are already present in the body in biologically active concentrations, additional exposure to relatively small amounts of exogenous hormonally active substances can disrupt the proper functioning of the body's endocrine system. Thus, an endocrine disruptor can elicit adverse effects at much lower doses than a toxicity, acting through a different mechanism.

The timing of exposure is also critical. Most critical stages of development occur in utero, where the fertilized egg divides, rapidly developing every structure of a fully formed baby, including much of the wiring in the brain. Interfering with the hormonal communication in utero can have profound effects both structurally and toward brain development. Depending on the stage of reproductive development, interference with hormonal signaling can result in irreversible effects not seen in adults exposed to the same dose for the same length of time. Experiments with animals have identified critical developmental time points in utero and days after birth when exposure to chemicals that interfere with or mimic hormones have adverse effects that persist into adulthood. Disruption of thyroid function early in development may be the cause of abnormal sexual development in both males and females early motor development impairment,and learning disabilities.